Equidone® (Domperidone) Oral Gel
80316-397
- The only FDA vet-labeled product for preventing fescue toxicosis
- Increases milk production in mares after foaling
- Blocks dopamine receptors that toxins bind to
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- This product is available by prescription only.
- Due to federal and state laws, we cannot accept returns on prescription items.
- The only FDA vet-labeled product for preventing fescue toxicosis
- Increases milk production in mares after foaling
- Blocks dopamine receptors that toxins bind to
- Convenient dosing ring for easy administration
- Contains domperidone for horses
Equidone® Gel is for use in pregnant mares to prevent and treat fescue toxicosis or to be used after foaling to aid in milk production by the mare.
Fescue toxicosis is caused by an endophyte in fescue grass and can lead to increased gestation lengths, poor udder development, foaling problems and low or no milk production in mares. The use of Equidone® Gel greatly reduces these complications and can increase milk production in mares after foaling.
Fescue toxicosis can be very costly to a horse owner especially when it results in death of the mare and/or foal. Equidone® Gel contains domperidone for horses and is the only FDA vet-labeled product for preventing clinical signs associated with fescue toxicosis in periparturient mares.
Equidone® Gel counteracts the effects of fungal toxins released by fescue toxicosis and blocks dopamine receptors that toxins (produced by the endophyte Neotyphodium coenophialum) bind to. Features a convenient dosing ring for easy administration.
Active Ingredients: Equidone® Gel is supplied in disposable, multi-dose, 25 cc syringes, each containing 2.75 g of domperidone suspended in an oral gel. Each cc of gel contains 110 mg of domperidone.
Storage: Store at controlled room temperature 25°C (77°F) with excursions between 15°- 30°C (59°-86°F) permitted. Recap after each use.
Side Effects: The most common adverse reactions associated with the treatment with Equidone® Gel are premature lactation and failure of passive transfer.
Warnings: Horses with hypersensitivity to domperidone should not receive Equidone® Gel.
Do not use in horses intended for human consumption.
Failure of passive transfer of immunoglobulins (IgG) may occur when using Equidone® Gel even in the absence of leakage of colostrum or milk. All foals born to mares treated with Equidone® Gel should be tested for serum IgG concentrations.
Precautions: Equidone® Gel may lead to premature birth, low birth weight foals or foal morbidity if administered > 15 days prior to the expected foaling date. Accurate breeding date(s) and an expected foaling date are needed for the safe use of Equidone® Gel.
The safety of Equidone® Gel has not been evaluated in breeding, pregnant and lactating mares other than in the last 45 days of pregnancy and the first 15 days of lactation. The safety in stallions has not been evaluated. The long-term effects on foals born to mares treated with Equidone® Gel have not been evaluated.
Do not use in horses with suspected or confirmed gastrointestinal blockage, as domperidone is a prokinetic drug (it stimulates gut motility).
Use of Equidone® Gel may cause a false positive on the milk calcium test used to predict foaling.
Domperidone is a known P-glycoprotein substrate1 and its main metabolic pathway in humans is through CYP3A4. Significant inhibition of domperidone metabolism may occur when co-administered with drugs such as erythromycin2 and ketoconazole3. This could result in significantly greater domperidone drug exposure (multi-fold increase) when used with these drugs.
Human Precaution: Pregnant and lactating women should use caution when handling Equidone® Gel, as systemic exposure to domperidone may affect reproductive hormones. Domperidone is not approved for any indication in humans in the US. The safety of domperidone in lactating women and their nursing children has not been evaluated. Consult a physician in case of accidental human exposure.
Overdoses can be very dangerous. Keep out of reach of children and animals.
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
This medication should only be given to the pet for whom it was prescribed.
Disposal of Unused Prescription Medications
- Return unwanted or unused medications to Revival Animal Health in person, or visit www.disposemymeds.org to find a pharmacy near you.
- A secondary method of drug disposal is to remove the unwanted medication from any wrappers or containers and place it in a plastic bag with moist coffee grounds or cat litter. This can be disposed of in the regular garbage collection.
- Please do NOT dispose of unwanted meds down the drain or toilet, as this may eventually find its way into the human water supply.
Learn more about disposal of unused prescription medications here.
Disposal of Medical Sharps
- When you're finished with the syringe and needle, do not try to recap, remove, bend or break the needle. This is where most injuries occur.
- Dispose the syringe and needle immediately in a nearby sharps container. All sharps must be deposited in a puncture-proof container. Make sure your storage location is child and animal proof.
- As with all product handling, make sure you wash your hands after handling medical sharps.
Disposal of Sharps Container
- When your sharps container is half-full, sift dry Portland Cement throughout the sharps. Fill the container with water, and rotate until the cement is mixed and the sharps have been distributed throughout the cement mixture. Let cement dry for 24 hours.
- Seal the lid of the container tightly and use duct tape to seal. Label the container "Livestock Sharps" to properly identify the contents.
- Dispose of the containers in accordance with your state's regulations.
Our pharmacy hours are Monday-Friday 8:00 a.m. − 4:30 p.m. CST.