Sentinel® Flavor Tabs® is a once a month oral medication that protects dogs and puppies against Heartworm disease (Dirofilaria immitus) and fleas, with additional protection against the three most common intestinal worms: roundworms, hookworms and whipworms. Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of Milbemycin Oxime and 4.55 mg/pound (10 mg/kg) body weight of Lufenuron. Milbemycin Oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis, Toxoascaris leonine) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Lufenuron, the other active ingredient, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. The concurrent use of an approved adulticide such as Capstar® Tablets (Nitenpyram) may be needed to provide a flea management system that kills adult fleas and prevents flea eggs from hatching especially if dogs have repeated exposure to flea infested environments or animals.
Sentinel® Flavor Tabs® are available in in four tablet sizes and formulated according to the weight of the dog. Each tablet size is available in color-coded packages of 6 tablets per package.
Brown: 2-10 lbs
Green: 11-25 lbs
Yellow: 26-50 lbs
White: 51-100 lbs
Active ingredients: Milbemycin Oxime and Lufenuron
Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C).
Well tolerated at the veterinarian's recommended dosage.
The following adverse reactions have been reported in dogs after giving Milbemycin Oxime or Lufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation and weakness.
There are no known food or drug interactions, and Sentinel® is considered safe in pregnant and lactating animals.
Do not use in puppies less than four weeks of age and less than two pounds of body weight.
Prior to administration of Sentinel® Flavor Tabs®, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with Sentinel® Flavor Tabs®. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.
Sentinel® Flavor Tabs® immediately break the flea life cycle by inhibiting egg development. However, pre-existing flea populations may continue to develop and emerge after treatment with Sentinel® Flavor Tabs® has begun. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of an approved adulticide, like Capstar® may be employed depending on the severity of the infestation.
If a Sentinel® Flavor Tabs®-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. The temporary use of an adulticide product may be necessary to kill these adult fleas.
The safety of the concurrent use of Sentinel® Flavor Tabs® and Capstar® Tablets in pregnant or nursing dogs or in puppies less than 11 weeks of age has not been demonstrated.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Keep out of the reach of children
|Recommended Dosage Schedule|
|2 to 10 lbs
|11 to 25 lbs
|26 to 50 lbs
|51 to 100 lbs
For concurrent dosing of Sentinel®
Tablets, see package insert.
are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets. Administer Sentinel®
to dogs, immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of Lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.
must be administered monthly, preferably on the same date each month. Treatment with Sentinel®
may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of “mosquito and flea season.” In areas with year-round infestations, treatment should continue through the entire year without interruption.
If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel®
immediately and resume the monthly dosing schedule. If Sentinel®
replace daily diethylcarbamazine (DEC) for Heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.